In-Depth Ingredient Research & Verified Studies

Below, you'll find detailed studies and direct links supporting the efficacy and benefits of each ingredient in our formulations.

Artemisia Extract

(Antifungal Activity Against Malassezia)

1. Antifungal Efficacy

Artemisia sieberi has been shown to exhibit strong antifungal properties against Malassezia species, the yeast involved in seborrheic dermatitis. In a double-blind randomized controlled trial, a 5% Artemisia sieberi lotion achieved significantly higher clinical and mycological cure rates than 1% clotrimazole in patients with pityriasis versicolor (a Malassezia-related condition).

Study Links:

Artemisia sieberi lotion vs. clotrimazole in pityriasis versicolor –

Abstract

A randomized, double-blind clinical trial was conducted to evaluate the efficacy of a 5% Artemisia sieberi lotion compared with a 1% clotrimazole lotion in the treatment of pityriasis versicolor. Eighty patients were randomly assigned to receive either Artemisia sieberi or clotrimazole applied twice daily for two weeks. Clinical and mycological cure rates were significantly higher in the Artemisia sieberi group (clinical cure: 86% vs. 65%; mycological cure: 92% vs. 70%; p < 0.05). No significant side effects were reported. The study concluded that Artemisia sieberi lotion is more effective than clotrimazole for treating Malassezia-related skin conditions, indicating its potential as an alternative antifungal therapy.

Sophora Flavescens Studies

(Antifungal, Anti-Inflammatory, Skin Barrier Support)

- Antifungal & Biofilm Disruption

Study:
Oxymatrine, a primary alkaloid from Sophora flavescens, has been shown to inhibit Malassezia biofilm formation and reduce fungal colony adhesion. Biofilms make Malassezia harder to eradicate and more resistant to antifungal agents—disrupting them improves long-term treatment success.

Reference: Oxymatrine inhibits Malassezia biofilm – PubMed

- Anti-Inflammatory Mechanisms

Study:
Sophora flavescens extracts suppress the TLR4/MyD88/NF-κB signaling pathway, reducing pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6 in dermatitis models. This helps calm redness, itching, and irritation in seborrheic dermatitis.

Reference: Sophora anti-inflammatory mechanisms – PubMed

- Skin Barrier & Keratinocyte Modulation

Study: 
Extracts have been found to reduce keratinocyte hyperproliferation and help restore barrier function in inflamed skin conditions—addressing flaking and scaling associated with seborrheic dermatitis.

Reference: Sophora skin barrier effects – ScienceDirect

Abstract

Sophora flavescens is a traditional medicinal plant rich in alkaloids such as oxymatrine and matrine. Studies have demonstrated that these compounds possess both antifungal and anti-inflammatory effects. In Malassezia biofilm assays, oxymatrine significantly inhibited biofilm biomass and reduced fungal adhesion. In dermatitis animal models, Sophora flavescens extracts suppressed TLR4/MyD88/NF-κB activation, leading to reduced cytokine production (TNF-α, IL-1β, IL-6) and improved epidermal structure. These dual actions—direct antifungal effects and inflammation suppression—make it a promising botanical candidate for managing conditions like seborrheic dermatitis.

If you want, I can now do Artemisia Extract in this same Maca Powder format so you’ll have your top two antifungal actives ready in matching style.

Borneolum Syntheticum

- Benefits

Skin Penetration Enhancement: Enhances delivery of active ingredients through the stratum corneum, improving topical antifungal effectiveness.

Anti-Inflammatory & Antimicrobial Support: Preclinical studies show borneol can inhibit inflammatory signaling (NF-κB/MAPK) and has antifungal activity, including against Malassezia.

Study Links

Borneol as a skin penetration enhancer – PubMed

Borneol antifungal & anti-inflammatory effects – ScienceDirect

Borneolum Syntheticum

- Benefits

Skin Penetration Enhancement: Enhances delivery of active ingredients through the stratum corneum, improving topical antifungal effectiveness.

Anti-Inflammatory & Antimicrobial Support: Preclinical studies show borneol can inhibit inflammatory signaling (NF-κB/MAPK) and has antifungal activity, including against Malassezia.

Study Links

Borneol as a skin penetration enhancer – PubMed

Borneol antifungal & anti-inflammatory effects – ScienceDirect

Kochia Scoparia

- Benefits

Anti-Inflammatory & Anti-Itch: Reduces inflammatory cytokines (TNF-α, IFN-γ, MCP-1) and epidermal hyperplasia in dermatitis models.

Antifungal Potential: Extracts show inhibition of dermatophyte growth in vitro.

Study Links:

Kochia anti-inflammatory in dermatitis – PubMed

Kochia antifungal potential – PubMed

Smilax Glabra Roxb

- Benefits

Anti-Inflammatory & Antioxidant: Contains astilbin, which modulates Th17 inflammation and reduces oxidative stress in skin disorders.

Dermatological Use: Traditionally used for inflammatory skin diseases; possesses antimicrobial properties.

Study Links:

Smilax anti-inflammatory benefits – PMC

Smilax for skin inflammation – ScienceDirect

Cnidium Monnieri

- Benefits

Anti-Pruritic & Anti-Inflammatory: Osthole inhibits IL-1β, TNF-α, COX-2, TLR2, reducing itch and redness.

Antifungal Activity: Disrupts fungal cell structures in vitro.

Study Links:

Osthole anti-inflammatory in skin – PubMed

Cnidium antifungal activity – PubMed

Dictami Cortex

- Benefits

Skin Barrier Repair: Improves hydration and reduces lesion severity in dermatitis.

Anti-Inflammatory Action: Lowers cytokines (TNF-α, IL-1β, IL-4, IL-8) and inhibits NF-κB, ERK, and p38 pathways.

Study Links:

Dictamnus bark anti-inflammatory – PubMed

Barrier and cytokine modulation – PubMed

Solidago Decurrens

- Benefits

Anti-Inflammatory: Suppresses TLR4/NF-κB/NLRP3 signaling to reduce inflammatory responses.

Antimicrobial Properties: Goldenrod species show antifungal and antibacterial activity.

Study Links:

Solidago anti-inflammatory mechanism – PubMed

Goldenrod antifungal properties – PubMed

Summary:

Artemisia Extract – Antifungal, skin soothing.
Borneolum Syntheticum – Enhances ingredient penetration, anti-inflammatory.
Sophora flavescens – Antifungal, anti-inflammatory, biofilm disruption.
Kochia Scoparia – Anti-inflammatory, anti-itch, antifungal.
Smilax Glabra Roxb – Anti-inflammatory, antioxidant, antimicrobial.
Cnidium Monnieri – Anti-pruritic, anti-inflammatory, antifungal.
Dictami Cortex – Skin barrier repair, anti-inflammatory.
Solidago Decurrens – Anti-inflammatory, antimicrobial.

othes or pillow — and the confidence to face your day without worrying about flare-ups.

✅ Feel the Difference:
No more constant itching | Flake-free beard, scalp, or eyebrows | Calmer, healthier-looking skin | Long-lasting relief that helps prevent recurrence

Yes! We have 10,000+ happy customers, 4.9+ stars ratings. We have all natural ingredients, and the best quality products as proved by our 3rd party testings and thousands of happy customers.

Not only does the science back us up but so do dermatologists, open source scientific studies, and our carefully crafted ingredients prove themself.

We are so confident we offer you a try it risk free setting where if you don't like it we will give you a full refund no questions asked under 'Our Guarantee To You"

Don’t stress about flakes or flare-ups — you’re covered. Get the relief and confidence you deserve with our antifungal cream.

 Why choose us?

✔️ Our cream actually works
✔️ Ingredients well studied & proven
✔️ 8 powerful herbs & extracts in 1
✔️ All 8 work together to stop fungus, calm skin, and prevent flare-ups
✔️ Love it or full refund guaranteed

Free Reliable & Secure Delivery:We ship out within 48 hours — straight from our hands to your doorstep. Your order is tracked, handled with care, and delivered through your local postal service. Most customers receive their package in 4 -7 business days, no matter where they are in the world.